Le bonheur; le bonheur est là, à notre portée. Il suffit de nous y mettre immédiatement! Audacieuse, étonnante, renversante, la philosophie de Robert Misrahi nous embarque. Elle est à lire par gros temps, elle agit comme un remontant. Cette pensée solaire est un élan, une force, un souffle qui nous réveille. Elle ravive la liberté, chante le Désir, célèbre la réflexion, matériaux essentiels à la construction de notre joie et de notre bonheur. Cette introduction à la philosophie misrahienne est une (...) invitation à ce beau voyage. Simple, didactique et pratique, elle donne envie de vagabonder, de sillonner, d'explorer et peu à peu d'aller vers le grand large, vers l'œuvre entière. Elle est destinée à tous. Cher lecteur, hâte-toi, hâte-toi donc d'embarquer pour la joie et le bonheur!"--Page 4 of cover. (shrink)

Que peut-on attendre d'un « citoyen du monde » dans l'espace européen à venir? Que représente le cosmopolitisme en Europe? Voici quelques-unes des questions posées par cet ouvrage qui présente les réflexions de chercheurs européens et non européens sur le cosmopolitisme. Les regards des spécialistes sur la question sont variés et la réalité est analysée à partir de différentes disciplines. Ainsi, science politique, histoire, droit, langues, littérature et civilisation se conjuguent pour présenter une vision toujours évolutive, parfois idéale, du cosmopolitisme. (...) On considère souvent le cosmopolitisme comme obsolète. N'est-ce pas, au contraire, une des réponses possibles à la crise que traverse l'Union européenne en ce début de XXIe siècle? (shrink)

A partir de réflexions qui mettent en perspective différentes approches philosophiques, cet ouvrage présente une vision prospective de la philosophie - vision pensée sous l'horizon de la philosophie grecque. La philosophie ne peut, semble t-il, se développer indépendamment de toute référence grecque, c'est-à-dire aussi de ce qui constitue son origine. L'enjeu est de tracer les contours d'une philosophie à venir à partir d'une réflexion sur une contribution possible ou nécessaire de la philosophie grecque. On s'interroge sur le sens, les significations (...) et la pertinence de la philosophie grecque aujourd'hui : y a-t-il une nécessité à revenir aux origines de la philosophie, à son premier moment grec? Quelle serait la nature d'une telle nécessité? En quoi la philosophie grecque pourrait-elle constituer une référence obligée et comment penser cette référence? Y a t-il une actualité de la philosophie grecque? Telles sont les différentes questions auxquelles les auteurs de ce livre ont tenté de répondre. (shrink)

Une longue introduction précède les contributions de ces trois philosophes et théologiens à la querelle sur la distinction entre l'être et l'essence qui anima la Faculté de théologie de l'Université de Paris dans les années 1280.

We discuss the latent variables construct, particularly in regard to the following: that latent variables are considered as the sole explanatory factor of a disorder; that pragmatic concerns are ignored; and that the relationship of these variables to biological markers is not addressed. Further, we comment on the relationship between bridge symptoms and causality, and discuss the proposal in relationship to other constructs (endophenotypes, connectionist-inspired networks).

This paper presents our work on textual inference and situates it within the context of the larger goals of machine reading. The textual inference task is to determine if the meaning of one text can be inferred from the meaning of another and from background knowledge. Our system generates semantic graphs as a representation of the meaning of a text. This paper presents new results for aligning pairs of semantic graphs, and proposes the application of natural logic to derive inference (...) decisions from those aligned pairs. We consider this work as first steps toward a system able to demonstrate broad-coverage text understanding and learning abilities. (shrink)

Second person social cognition cannot be restricted to dyadic interactions between two persons (the and the ). Many instances of social communication are triadic, and involve a third person (the ), which is the object of the interaction. We discuss neuropsychological and brain imaging data showing that triadic interactions involve dedicated brain networks distinct from those of dyadic interactions.

An anthology of writings from Plato and Aristotle, including an introductory essay on the history of ancient Greek philosophy and Greek Glossary.

We identify the ways the policies of leading international bioethics journals limit the participation of researchers working in the resource-constrained settings of low- and middle-income countries in the development of the field of bioethics. Lack of access to essential scholarly resources makes it extremely difficult, if not impossible, for many LMIC bioethicists to learn from, meaningfully engage in, and further contribute to the global bioethics discourse. Underrepresentation of LMIC perspectives in leading journals sustains the hegemony of Western bioethics, limits the (...) presentation of diverse moral visions of life, health, and medicine, and undermines aspirations to create a truly “global” bioethics. Limited attention to this problem indicates a lack of empathy and moral imagination on the part of bioethicists in high-income countries, raises questions about the ethics of bioethics, and highlights the urgent need to find ways to remedy this social injustice. (shrink)

Scientific study of dreams requires the most objective methods to reliably analyze dream content. In this context, artificial intelligence should prove useful for an automatic and non subjective scoring technique. Past research has utilized word search and emotional affiliation methods, to model and automatically match human judges’ scoring of dream report’s negative emotional tone. The current study added word associations to improve the model’s accuracy. Word associations were established using words’ frequency of co-occurrence with their defining words as found in (...) a dictionary and an encyclopedia. It was hypothesized that this addition would facilitate the machine learning model and improve its predictability beyond those of previous models. With a sample of 458 dreams, this model demonstrated an improvement in accuracy from 59% to 63% on the negative emotional tone scale, and for the first time reached an accuracy of 77% on the positive scale. (shrink)

Umberto Eco -- Stephen Jay Gould -- Jean-Claude Carrière -- Jean Delumeau.

How do bioethics gatekeepers located in wealthy nations treat bioethics workers from developing countries? Can the policies of leading international bioethics journals—based on a concern for profit that effectively restricts access for most researchers from developing countries—be ethically justified? We examined these policies focusing on the way they influence the ability of researchers in resource-poor countries to participate in the development of the field of bioethics. Eight of the fourteen leading bioethics journals are published by three transnational publishing houses, all (...) of which are based in wealthy nations. None of these eight journals participates in the Health InterNetwork Access to Research Initiative of the World Health Organization, a program that provides free or very low-cost online access to the major journals by researchers in developing countries. Lack of access to these essential resources makes it extremely difficult, if not impossible, for bioethicists in developing countries to learn from, and engage in, the global bioethics dialogue. Thus, exclusionary practices of leading bioethics journals sustain the hegemony of Western bioethics, raising serious questions about professed aspirations to create a truly “global” bioethics. This phenomenon indicates lack of empathy and moral imagination of bioethicists in developed countries, raises serious questions about the ethics of bioethics, and highlights the urgent need for creative solutions to remedy this social injustice. (shrink)

Poly(ADP‐ribosyl)ation is an immediate DNA‐damage‐dependent post‐translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP‐ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP‐1 (113 kDa), the founding member, and PARP‐2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding (...) novel PARPs now extends considerably the field of poly(ADP‐ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post‐translational modification of proteins. This review summarizes our present knowledge of this emerging superfamily, which might ultimately improve pharmacological strategies to enhance both antitumor efficacy and the treatment of a number of inflammatory and neurodegenerative disorders. A provisional nomenclature is proposed. BioEssays 26:882–893, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Limited research has been done among pregnant people participating in investigational drug trials. To enhance the ethical understanding of pregnant people’s perspectives on research participation, we sought to describe motives and risk perceptions of participants in a phase 1 trial of ledipasvir/sofosbuvir treatment for chronic Hepatitis C virus during pregnancy. Pregnant people with chronic HCV infection enrolled in an open-label, phase 1 study of LDV/SOF participated in semi-structured, in-depth interviews to explore their reasons for participation and experiences within the study. (...) Pregnant people took 12 weeks of LDV/SOF and were interviewed at enrollment and at the end of study. We recorded the interviews, transcribed them verbatim, coded them using NVivo software, and performed inductive thematic analysis. Nine women completed the study yielding 18 interview transcripts. We identified two themes regarding motives and one regarding risk perception. Motives— Women conceptualized study participation as part of the caregiving role they associate with motherhood; participating was viewed as an act of caregiving for their infants, their families, themselves, and other pregnant women with chronic HCV. Women also noted that they faced multiple barriers to treatment prior to pregnancy that created a desire to receive therapy through trial participation. Risk perception— Women acknowledged personal and fetal risk associated with participation. Acceptance of risk was influenced by women’s concepts of motherhood, preexisting knowledge of HCV and medical research, family members, intimate partners, or by the study design. Women enrolled in a phase 1 trial for chronic HCV therapy during pregnancy acknowledged risks of participation and were motivated by hopes for fetal and personal benefit and by lack of prenatal access to treatment. Ethical inclusion of pregnant people in research should acknowledge structural factors that contribute to vulnerability and data deficiencies for treatment in pregnancy. (shrink)

Research Ethics, Volume 18, Issue 2, Page 132-150, April 2022. Limited research has been done among pregnant people participating in investigational drug trials. To enhance the ethical understanding of pregnant people’s perspectives on research participation, we sought to describe motives and risk perceptions of participants in a phase 1 trial of ledipasvir/sofosbuvir treatment for chronic Hepatitis C virus during pregnancy. Pregnant people with chronic HCV infection enrolled in an open-label, phase 1 study of LDV/SOF participated in semi-structured, in-depth interviews to (...) explore their reasons for participation and experiences within the study. Pregnant people took 12 weeks of LDV/SOF and were interviewed at enrollment and at the end of study. We recorded the interviews, transcribed them verbatim, coded them using NVivo software, and performed inductive thematic analysis. Nine women completed the study yielding 18 interview transcripts. We identified two themes regarding motives and one regarding risk perception. Motives— Women conceptualized study participation as part of the caregiving role they associate with motherhood; participating was viewed as an act of caregiving for their infants, their families, themselves, and other pregnant women with chronic HCV. Women also noted that they faced multiple barriers to treatment prior to pregnancy that created a desire to receive therapy through trial participation. Risk perception— Women acknowledged personal and fetal risk associated with participation. Acceptance of risk was influenced by women’s concepts of motherhood, preexisting knowledge of HCV and medical research, family members, intimate partners, or by the study design. Women enrolled in a phase 1 trial for chronic HCV therapy during pregnancy acknowledged risks of participation and were motivated by hopes for fetal and personal benefit and by lack of prenatal access to treatment. Ethical inclusion of pregnant people in research should acknowledge structural factors that contribute to vulnerability and data deficiencies for treatment in pregnancy. (shrink)

v. 1. Cinq mémoires sur l'instruction publique -- v. 2. Rapport sur l'instruction publique.

Who are the gatekeepers in bioethics? Does editorial bias or institutional racism exist in leading bioethics journals? We analyzed the composition of the editorial boards of 14 leading bioethics journals by country. Categorizing these countries according to their Human Development Index (HDI), we discovered that approximately 95 percent of editorial board members are based in (very) high-HDI countries, less than 4 percent are from medium-HDI countries, and fewer than 1.5 percent are from low-HDI countries. Eight out of 14 leading bioethics (...) journals have no editorial board members from a medium- or low-HDI country. Eleven bioethics journals have no board members from low-HDI countries. This severe underrepresentation of bioethics scholars from developing countries on editorial boards suggests that bioethics may be affected by institutional racism, raising significant questions about the ethics of bioethics in a global context. (shrink)

La entrevista recorre conceptos como “las geopolíticas del conocimiento” aplicada a América Latina y postula que la región es un producto geopolítico fabricado e impuesto por la “modernidad”, donde “América Latina” se fue fabricando como algo desplazado de la modernidad; o a la filosofía, que se narra de Grecia a Europa, quedando todo el resto del planeta fuera de la historia de la filosofía. Invita el entrevistado a dejar de pensar que lo que vale como conocimiento está en ciertas lenguas (...) y viene de ciertos lugares. Recorre desde este enfoque temas como la infección recíproca entre cosmología indígena y cosmología marxista; la distinción entre "interculturalidad" y "multiculturalidad.", y la re-articulación del poder en la "cuarta guerra mundial.". (shrink)

Cet ouvrage prend pour objet les effets de la féminisation massive des activités équestres depuis l’après-guerre, tant au niveau statistique que du point de vue du contenu des pratiques. Le sous-titre choisi établit une certaine ambigüité sur la démarche adoptée : il pose la question d’une « avancée », c’est à dire d’un progrès que constituerait ou non la présence des femmes dans le domaine équestre. « Avancée » (mise ici en doute) pour qui? Pour les femmes? Pour les chevaux? (...) Pour l’activi... (shrink)

Focalisé sur un problème posé par Bernard Frenicle de Bessy vers 1639, sa solution et les réponses de ses correspondants, cet article s'attache à décrire plusieurs registres enchevêtrés de l'expérience du mathématicien: expérimentation sur les nombres empruntée en partie aux sciences de la nature, injonctions d'une pratique collective cimentée par les problèmes et leurs constructions explicites, entraînement personnel de l'attention et du savoir-faire s'articulent ainsi dans les efforts de Frenicle pour contester la suprématie de l'analyse algébrique et dans les modes (...) de conviction qui fondent son travail. Ce récit d'expérience permet en retour d'apprécier les problèmes que posèrent à Frenicle la transmission de ses résultats et, à ses historiens, la restitution de son activité. (shrink)

Distincte de la responsabilité managériale et de la responsabilité pénale, la responsabilité financière des gestionnaires publics, qui vise à protéger la régularité de la gestion publique, s’inscrit, en France, dans une longue tradition : le contrôle et la responsabilité sont même indissociablement liés à l’existence même des juridictions financières, dont la Cour des comptes constitue le cœur. Si les fondements philosophiques de cette responsabilité demeurent plus que jamais d’actualité, dans un contexte de perte de confiance des citoyens en l’action publique, (...) les modalités pratiques de l’exigence faite aux gestionnaires publics de « rendre compte », et partant de leur responsabilité individuelle, doivent, pour être justes et efficaces, s’adapter en permanence aux évolutions des modes de gestion : la réforme en profondeur des régimes de responsabilité de droit public financier, annoncée pour 2022, en offre un exemple particulièrement pertinent et actuel. Toutefois, la crédibilité dans la durée du nouveau régime dépendra à la fois de la plasticité des infractions et du développement, en amont, de contrôles de régularité pertinents permettant « d’alimenter » le contentieux financier. (shrink)